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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

They target different aspects of aging biology and are sometimes used together in anti-aging research stacks

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The biological rationale is that the body's healing program is itself coordinated, so supporting cell migration and local repair signaling together, rather than in isolation, is intended to better match how tissue actually rebuilds

10.1016/j.aquaculture.2015.04.021 5 AtencioL.MorenoI.Jos.PrietoA